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The four EF-hands can bind four Ca 2+ , and different calmodulin sensing proteins operate downstream signalling

Liu Y, Dong M, Yang Z, Pan S

It turns out its not always a case of just needing to drink a glass of water

However, drug resistance against chemotherapeutic agents is a major issue reducing the success of treatment, as well as the high incidence of metastases causing poor prognosis and, most importantly, mortality (Nedeljkovic and Damjanovic 2019)