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An approved drug that inhibits NADH:ubiquinone oxidoreductase is the biguanide metformin 41 , the first-line treatment in type II diabetes 41

The cumulative amount of exposure is a function of both the rate and duration of exposure

Resting conidia are surrounded by a rodlet layer composed of hydrophobic RodA proteins (18, 80, 131, 132)

Moreover, ketone bodies are also important in the synaptic vesicular cycle (41), KD can also affect neurotransmitter levels in the synaptic cleft and increase GABA levels in addition to altering glutamate metabolism (42)