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This imbalance is closely linked to the pathogenesis of chronic metabolic disorders, such as diabetes mellitus, as well as chronic inflammatory diseases, including periodontal diseases

AGEs and methylglyoxal induce apoptosis and expression of Mac-1 on neutrophils resulting in platelet-neutrophil aggregation

Likewise, naringin also increases the expression of TJ proteins and the relative abundance of Firmicutes/Bacteroides while reducing the content of Proteobacteria to improve the intestinal flora disorder caused by DSS [157]