l carnitine autismweb Autism and carnitine: A possible

Additionally, small molecules often exhibit multiple unintended biological targets and such off-target effects may lead to preclinical and even clinical toxicities ( To mitigate the risk of false positives in preclinical drug discovery, several practices are recommended

These effects possibly result from its potential to inhibit or alter cytochrome P450 enzymes (CYP3A4, CYP2D6), leading to increased drug levels and overlapping side effects including gastrointestinal distress and myalgia

Belosludtsev KN, Belosludtseva NV, Dubinin MV

Of note, granulocyte colony stimulating factor is often used to support the mobilization of hematopoietic stem cells after bone marrow transplantation or following high-dose multi-agent chemotherapy in children, although its use has been associated with higher risk for CIPN (Weintraub et al., 1996