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The protective effects may involve increased Tregs, rebalanced Th1/Th2/Th17 cells, and a less proinflammatory immunological milieu in the gut, peripheral lymph nodes (pLN), and pancreas

Meanwhile, mRNA levels of individual TET family members ( TET1 TET3 ) remained largely comparable between shCtrl and shGDH1 cells (Extended Data Fig

2) Cell type- and subtype-specific regulatory blank spots: Most studies have centered on podocytes and TECs, but the role of renal non-parenchymal cells (e.g., mesangial cells, renal endothelial cells, and inflammatory cells) in ferroptosis-driven DN is understudied