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Daniel Goldenberg, Hadassah-Hebrew University Medical Center) and wild-type (WT) mice (FVB/N, ENVIGO), males and females, were maintained under specific pathogen-free conditions with a 12-h-light-dark cycle and permitted ad libitum consumption of water and standard chow

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In this context, SAM administration may act as a precursor for GSH synthesis and also bypass the deficiency in SAM synthetase

Combining compounds multiplies the variables in an experiment and makes results harder to read, so researchers plan these designs carefully and change one factor at a time