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While aminoguanidine has not been evaluated in diabetic CVD in clinical studies, a phase III randomized trial by Bolton et al

A meta-analysis of global birth prevalence of spina bifida showed that when a national, mandatory program to fortify the diet with folate was compared to countries without such a fortification program, there was a 30% reduction in live births with spina bifida

In founding the new field of orthomolecular psychiatry ("Orthomolecular Psychiatry" Science 160:265-271, 1968), Pauling proposed that mental abnormalities might be successfully treated by correcting imbalances or deficiencies among naturally occurring biochemical constituents of the brain, notably vitamins and other micronutrients, as an alternative to the administration of potent synthetic psychoactive drugs

To compare and analyze the impact of these potential modifications, we ran a simulation using the claims data from the September 2022 update of the FY 2022 MedPAR file