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Description

GCLC encodes the rate-limiting enzyme in glutathione synthesis glutamate-cysteine ligase catalytic subunit

Clin Endocrinol (Oxf) (2013) 79:58490

Concomitantly, no significantly decreased tumor size was noted for HCT116 GSTA4 -derived xenografts treated with oxaliplatin compared to the untreated group ( Figure 7E )

Additionally, significant improvements in ORR and clinical outcomes have been seen with combinations with immunomodulatory drugs (IMiDs), such as lenalidomide and pomalidomide, and the proteasome inhibitors (PI) bortezomib and carfilzomib (Fig