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Several studies have also demonstrated that AML-relevant MSC functions are altered by iron and/or iron overload, as summarized in Table 2 [100,101,102,103,104,105,106,107]: The release of several cytokines is reduced, and these modulations can have both direct effects on the AML cells and indirect effects via immunocompetent or endothelial cells (angiogenesis and vascular stem cell niches)