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Despite the therapeutic potential of the NRF2-BACH1 axis, very few BACH1 inhibitors, namely, heme, cannabidiol (CBD) and HPPE (N-(2-(2-hydroxyethoxy)ethyl)-1-methyl-2-((6-(trifluoromethyl)benzo[d]thiazol-2-yl)amino)-1H-benzo[d]imidazole-5-carboxamide have been tested in pre-clinical settings of neurodegenerative diseases up to date

The isolated effector domain exists primarily as a monomer in solution, but forms a hexamer ring in crystal via tandem association between adjacent protomers, and two hexamers are linked by the crystallographic 2-fold symmetry to generate a dodecamer [323]

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Uptake and metabolism of folate, vitamins B 6 and B 12 , choline, betaine, serine, and glycine may influence the methyl donor pool, and, ultimately, degrees of methylation modifications (Sapienza and Issa, 2016)