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CTCF, a CCCTC-binding factor, is a known transcriptional suppressor of c-Myc, but its inhibitory effect is reduced after phosphorylation [41, 42], possibly because of the fact that phosphorylation of CTCF reduces its DNA-binding activity [43]

Impaired iron recycling from erythrocytes is an early hallmark of aging

Their study also demonstrated its potential antioxidant protection against ROS damage [209]

The molecular mechanism underlying this observation remains to be determined, given that PPAR does not regulate genes involved in cholesterol uptake or efflux in aortas