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Amino Acid Sensors Although multiple mechanisms are involved in sensing amino acids within the intracellular space, it has been well established that the presence or absence of amino acids is sensed by distinct signaling pathways which involve the mechanistic target of rapamycin (mTOR) or the general control nonderepressible 2 (GCN2) ( mTOR activity is regulated by amino acid availability, energy levels, and growth factors ( via its metabolic product -ketoglutarate which is generated during glutaminolysis ( Table 1 ) ( 2+ fluxing in patients with SLE ( Table 1 Tentative therapeutic targets identified in studies of amino acid metabolism in T cells

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10.1097/01.WCB.0000081369.51727.6F 29 ChuquetJ.QuilichiniP.NimchinskyE

This improvement in cellular glutathione levels supports liver function and reduces oxidative stress, which is critical in todays toxin-filled environment