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Indeed, polymorphism in the Arsenic (+3 oxidation state) MethylTransferase ( AS3MT ) gene has been demonstrated to be a strong determinant of arsenic methylation capacity and related health outcomes as covered in reviews by Abuawad et al (2021) and Thomas (2021)

Similar content being viewed by others Introduction As a chronic disease, Obesity characterized by excessive or abnormally distributed adipose tissue (AT) accumulation, is clinically defined by body mass index (BMI 30 kg/m 2 ) and recognized as a multifactorial disorder driven by systemic energy imbalance [1,2,3]

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Consistent with this finding, upregulation of Cx43 hemichannels was observed in an AD mouse model (Mei et al., 2010), and AD patients displayed higher levels of ATP in brain regions surrounding -amyloid plaques (Mecheri et al., 1997