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If the cellular mechanisms to scavenge ROS are inadequate, they can trigger free radical chain reactions that further damage proteins, lipids, and nucleic acids, potentially leading to various disease conditions (Craft et al

2012).The overall architecture of the MSC has not yet been resolved, although some structures of subcomplexes have been crystalized (Norcum and Warrington 1998

Dose-dependent increases in cytokines/growth factors VEGF-A and sVEGFR-2 were reported in HUVEC but not in IMR-90 cells (Alleva et al., 2011)