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However, when the concentration of CORT exceeds 300 ng/ml, the protein expression level of NLRP3 gradually decreases, reaching its lowest level at 700 ng/ml, along with a decrease in activated caspase-1 expression

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In this aspect, astrocytic terminal processes, known as endfeet, contact the brain vasculature and enwrap the neuronal synapses, enabling the modulation of both neuronal activity and cerebral blood flow, following an elevation in intracellular Ca 2+ levels in the endfeets [24,29]