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Participants Participants between the ages of 18 and 50 were eligible if they met Diagnostic and Statistical Manual of Mental Disorders (fifth edition) criteria for a current single or recurrent episode of MDD, without psychotic features, based on clinical assessment and as documented by the Mini-International Neuropsychiatric Interview (v.7.0.2) 52

They concluded that that too much melatonin may negatively affect the melatonin phase-response curve [281]

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