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7.1 Identification of gutliver axisrelated therapeutic targets The future studies to systematically identify key molecular targets involved in gutliver communication during cadmium exposure, including intestinal barrier regulators, bile acid signaling pathways, microbial metabolites, and inflammatory mediators, which may serve as potential intervention targets

The K d values were determined using nonlinear least-squares analysis and the equation: where [ L ] is concentration of the peptide, [ P ] is concentration of the protein, I is the observed change of signal intensity and I max is the difference in signal intensity of the free and bound states of the protein

Although almost all these flavonoids could improve hepatic oxidative stress, liver inflammation and lipid metabolism regardless of their etiologies, the minimum effective dose and efficacies vary considerably among diseases

doi: 10.1016/j.neurobiolaging.2019.12.013