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The translocation of nuclear-encoded DNMT1 into the mitochondria matrix is guided by a conserved mitochondrial targeting sequence, and its activity has been shown to influence transcription from both heavy and light mtDNA strands [35] (Fig

In renal tissue, acute or chronic systemic injections of trimetazidine have been shown to reduce thiobarbituric acid reactive substances in immunosuppressant-induced renal dysfunction [178] and prevent SOD, glutathione peroxidase, catalase or glutathione decrease in ischemia/reperfusion injury in rats [179, 180]