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There is a possible link between potential oxidant effects of nicotine demonstrated in this study and its modulation of ALP mediated actions 47 , collagen and ECM formation in fibroblasts 50 , which could contribute to the effects of nicotine on wound healing, applicable to the cells used in our investigation

Acknowledgements The authors are grateful to the Panjab University, Chandigarh for research facilities, Ensembl Plants, URGI and NCBI for data availability