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Second layer: Results from the in vitro experiments would be validated with exhaled breath analysis

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[35] An evaluation of Providence, Rhode Islands 2012 tobacco policies that restricted the sale of flavored tobacco products (except menthol) to tobacco bars and restricted price discounting and multi-pack offers for tobacco products found them to be effective, with a reduction in high school students use of any tobacco products from 22.2% to 12.1% and current use of e-cigarettes from 13.3% to 6.6% following two years of rigorous enforcement of the policy