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Moreover, pharmacokinetic evaluations reveal that AOD 9604 has a short plasma half-life of about three to four minutes intravenously and slower absorption when administered orally

NNMT is an enzyme that catalyzes the transfer of a methyl group from S-adenosylmethionine (SAM) to nicotinamide (NAM), producing 1-methylnicotinamide (MNA) and S-adenosylhomocysteine (SAH)