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Whereas deficiencies in the enzymes (through genetic manipulation or use of inhibitors) exacerbate ischemia-reperfusion (I/R) injury, overexpression of these enzymes or treatment with pharmacological donors or inhaled gas therapy have been shown to have cytoprotective effects

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In particular, mitochondrial calcium uptake occurs via the mitochondrial calcium uniporter (MCU), a calcium-sensitive channel that, when opened by elevated cytosolic calcium, allows calcium to flow into the matrix down the mitochondrions steep electrochemical gradient [56, 57]

There are trials underway, and we expect that the vaccine will become available for certain age groups of children and for adolescents by late 2021 or early 2022