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The combination produced significantly better outcomes than either treatment alone in animal osteoarthritis models, with improved cartilage preservation and shorter functional recovery times

The genes normal function may be altered if it produces too many copies of itself (a process known as gene amplification) or too many copies of HER2 receptors (overexpression)

However, the LMM fitted with BWG as the dependent variable and NR, DMD, or AME as independent variables revealed a significant positive correlation between BWG and NR (F (1,53.9) = 15.12

But this is generally not an issue. Another potential side effect associated with lecanemab was amyloid-related imaging abnormalities with edema, or fluid formation on the brain