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Moreover, the observation that adding GLP-1MK-801 treatment on top of semaglutide leads to an additional weight loss of 7% in mice that have reached a weight loss plateau with semaglutide provides additional support for integrating NMDA receptor antagonism in next-generation weight loss therapeutics

As described in the Regulatory Impact Analysis of the CY 2025 PFS proposed rule (89 FR 62183 through 62184), excluding payment amounts for the selected codes from the specified calculations are not expected to result in an increase in spending beyond the expenditures that would otherwise occur under the statutory payment methodology in section 1899(d) of the Act

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