active site in glutathione transferases Roles for plant secondary metabolism Hepatocyte glutathione S-transferase mu 2

When a low dose of aspirin is administered orally (most commonly 81 mg), its context-sensitive drug disposition via the portal circulation combined with the difference in IC50 values for COX-1 vs COX-2 both contribute significantly to the high selectivity by which low dose oral aspirin inhibits platelet COX-1 vs other COX-2 found in other nucleated tissues such as the vascular endothelium (Pedersen & FitzGerald, 1984

However, for highly sensitive in vitro assays where maximum potency is required, research indicates that utilizing the solution within 14 days yields the most consistent experimental outcomes

Fernandez de Larrea C, Jimenez R, Rosinol L, Gine E, Tovar N, Cibeira MT et al

10.3389/fphar.2021.648708 158 XiaoC.WuQ.-P.CaiW.TanJ.-B.YangX.-B.ZhangJ.-M