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Metformin and Resveratrol Inhibited High Glucose-Induced Metabolic Memory of Endothelial Senescence through SIRT1/p300/p53/p21 Pathway

Under normal, unstressed conditions, Nrf2 is kept inactive in the cell's cytoplasm, bound to a repressor protein called Keap1 (Kelch-like ECH-associated protein 1)