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FISSs, largely caused by vaccines (although other materials have been implicated), have been recognized since 1991

Prog Neuropsychopharmacol Biol Psychiatry 32:145149 Kahbazi M, Ghoreishi A, Rahiminejad F, Mohammadi MR, Kamalipour A, Akhondzadeh S (2009) A randomized, double-blind and placebo-controlled trial of modafinil in children and adolescents with attention deficit and hyperactivity disorder

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These include smoking, poor diet, physical inactivity, and excessive alcohol consumption, as well as conditions such as high blood pressure, high cholesterol and/or triglycerides, diabetes and insulin resistance, obesity, sleep disorders, air pollution exposure, imbalanced gut microbiome, and certain bacterial and viral infections