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Food & Drug Administration, et al

This was more pronounced in trials for early-stage cancers, with protocol exclusion criteria on the basis of organ-system abnormalities and functional status limitations being associated with lower elderly participation (the authors estimate that relaxing those eligibility restrictions would increase their share to 60 percent) (Lewis et al., 2003)

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Hemorrhagic transformation occurs through a disruption in tight junction proteins, and investigations into this underlying mechanism found that dysregulated extracellular proteolysis in the vascular matrix after tPA contributes to hemorrhagic transformation (Chandler et al., 1990