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TrxR is a dimer with an N-terminal structural domain that contains the FAD cofactor, which is responsible for accepting electrons from NADPH, and a C-terminal structural domain that contains the conserved selenocysteine (Sec) active site, which is the end-site for electron transfer (28)

Liposomal versions wrap glutathione in tiny fat-like spheres designed to protect it through digestion so more reaches the bloodstream intact the appeal is better absorption than plain reduced glutathione, which the gut breaks down readily

Different frequencies and degrees of hypoxia have also been used as in vitro models of ECD [136]

In the OPC-like compartment, NTRK2 expression correlated with postsynaptic organization, axon guidance, neuronal projection guidance, neuronal migration, ERK signalling cascades and the AKT signalling cascade, consistent with the hypothesized role of TrkB in neuron-to-glioma synapses, consequent effects of AMPAR-mediated synaptic signalling on tumour migration 29 and expected signalling consequences of TrkB activation