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Studies have also tested higher doses without adverse reactions , which means that even higher doses can be considered as safe

The direct relationship between tryptophan levels and depressive symptoms and fatigue has been demonstrated by Trp depletion experiments, as reviewed elsewhere [76], and is also of interest in the context of long-term COVID, as recent studies have shown a significant decrease in plasma Trp levels in PASC patients [48], and alterations in kynurenine pathway metabolites have been associated with cognitive impairment in long COVID patients [27], as well as with anxiety and depressive symptoms in COVID-19 survivors 6 months post-infection [66]

In their case, the study presented a longer duration (24 weeks) than the study carried out by Smith et al

Nat Rev Endocrinol (2019) 15(5):28898