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NOTE ADDED IN PROOF After this article was submitted for publication on January 2, 2013, the following article was published prior to publication which strongly supports the hypothesis in the current article

Disease processes often cause the patient to present with jaundice due to hyperbilirubinemia

Elevation of intracellular Ca 2+ activates scramblase to ensure PS externalization, opens the Gardos channels, resulting in K + efflux and subsequent cell shrinkage, and mobilizes calpain, leading to cytoskeleton degradation and membrane microvesiculation [78]