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Add supplementation only if levels decline below 400 pg per milliliter or symptoms suggest deficiency

Additionally, it is crucial to recognize the existence of ME/CFS subtypes, such as those arising post-infection versus other causes, as well as the fluctuating nature and intensity of symptoms

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Chem Rev 121:32973351 White BH, Whalen K, Kriksciukaite K, Alargova R, Au Yeung T, Bazinet P, Brockman A, DuPont M, Oller H et al (2019) Discovery of an SSTR2-targeting maytansinoid conjugate (PEN-221) with potent activity in vitro and in vivo