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It is precisely due to distinctions in EC metabolism during Phase II (glucuronidation, sulfation, methylation) and its conversion capacity by the gut microbiota that variations arise in its in vivo exposure levels and the composition of EC and its active metabolites

French maritime pine bark extract significantly lowers the requirement for analgesic medication in dysmenorrhea: A multicenter, randomized, double-blind, placebo-controlled study

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Vesicular and nanocarriers The drug-carrying vesicles in transdermal delivery including liposomes and nanoparticles are one of the most promising methods which ease skin penetration as it improves fluidizing the skin lipids, the drug portioning into the skin, and drug solubilization into the formulations [289, 290]