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With a median follow-up of 16.6 months, the median PFS was 14.9 months (95% CI, 11.018.5) with the combination versus 7.3 months (95% CI, 5.68.2) with vemurafenib alone

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BOX 7-1 Lesion Characteristics in Nails That Should Raise a Red Flag Location: Single digit, thumb, or great toe nails Appearance: Fast growth, longitudinal melanonychia, band width more than 3-5 mm Hutchinsons Sign: Periungual pigmentation of skin Nail Dystrophy: Notch in free distal nail margin, surface irregularity, oozing, or bleeding lesion similar to ingrown nail Melanonychia striata Brown longitudinal stria (plural is striae) that occurs in the nail is called melanonychia striata

No higher incidence of MM or neurocutaneous melanocytosis was found based on the genotype