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High drug exposure leads to an increased risk of sinusoidal obstruction syndrome (SOS, an early complication of hematopoietic stem cell transplantation), whereas low drug exposure has been associated with a higher risk of disease recurrence and graft failure ( The aim of our study was therefore to identity gene polymorphisms involved in the metabolism of Cy and other drugs and correlate them with complications (GVHD, SOS, HC and TRM), after Haplo-HSCT

cerevisiae strain with pTEF1-GSH1 at the GSH1 locus on both alleles, and pGSH1-URA3 at the URA3 locus on both alleles was constructed (strain designated homozygous pGSH1-URA3 in the following context) (Figure S1 B )

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Peptide therapy is typically administered through small subcutaneous injections, often near the affected area to maximize localized healing