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All models were controlled for confounders such as gestational age, maternal age, maternal SES, pre-pregnancy BMI, and fetal sex

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In a long-term study (10 years follow-up), including 86 patients with adult-onset pituitary disease who received HGH replacement therapy, four patients died, one from renal carcinoma, one from omental cancer, one from pulmonary edema (probably secondary to an acute myocardial infarction), and a fourth from cerebral infarction