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Additional pumping stations for sludge movement, final sedimentation tanks and larger aeration tanks further increase overall construction costs

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The MSH-dependent alcohol dehydrogenase MscR (MSNO reductase/formaldehyde dehydrogenase) catalyzes the detoxification of formaldehyde and S -nitrosyl-mycothiol (MSNO) (Newton et al., 2008)

If conjugation of HMCDs with anti-neoplastic agents increases the intracellular drug concentration, it is likely the conjugate will bind to different, or additional drug targets, increasing the potency relative to the unconjugated drug