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To ensure effective and stable intracerebral drug concentrations, continuous optimization of delivery systems is pursued, exemplified by hyperpermeable selenium nanoparticles coupled with focused ultrasound for precise antibody targeting

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Although these agents are effective, their usage is limited due to various associated side effects like hypersensitivity, renal disease, hypertension, cardiac complications, gastrointestinal damage, respiratory difficulty, ulcer, and immune suppression, leading to opportunistic infections