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Decreases in weight gain and nasal pathological effects were noted in rats exposed to 1,2-dibromoethane at 115 mg/m 3 (578 ppm) for 6 h/day, 5 days/week, for 13 weeks

The brain interprets this as a state of low estrogen, responds by releasing more GnRH, which triggers more LH and FSH secretion, which in turn drives the testes to produce more testosterone