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Emerging evidence from recent in vitro studies and clinical trials indicates an inverse correlation between SCFA concentrations in the gut and the prevalence of disorders, including colorectal cancer, IBD, and diabetes

While our current analysis focused specifically on differentiated enterocytes, further investigations are required to elucidate the full spectrum of contributing differentiated populations and to define the hierarchical relationships that govern their regenerative potential

TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death

This suggests that neuronal degeneration may lead to local release of iron, which is subsequently scavenged and stored by microglia to maintain brain iron homeostasis (346)