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Taqman-based quantitative real time PCR was performed using the SuperScript III Platinum One-Step qRT-PCR reagent (Thermo Fisher #11732088)

HNMT works on the absorbed histamine, metabolizing it using SAMe as methyl donor

Nature 608 , 192198 (2022)

Small compounds such as PRIMA-1 (APR-017), APR-246 (Eprenetapopt), and COTI-2 restore mutant p53 to a functional state, reactivating its tumor-suppressive capabilities, with potential therapeutic uses in a variety of malignancies (Devor et al., 2021)