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A full list of survey questions can be found in Supplementary Table 24

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Polo-like kinase (PLK) and creatine kinase (CK) are the main kinases promoting -syn phosphorylation [14], while PP2A is the main phosphatase promoting -syn dephosphorylation [15]

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This means pyridoxine may provide proportionally greater benefit for semaglutide users than tirzepatide users, simply because the baseline nausea burden is higher

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Without comprehensive clinical data, it is impossible to predict or manage these risks effectively

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