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Before cytokine stimulation, cultures were pre-treated for 1 h with 25 M 6-amino-1,4-dihydro-4-[5-(hydroxymethyl) (SHIN1), a serine hydroxymethyltransferase 1 and 2 (SHMT1/SHMT2) inhibitor (MedChemExpress, Monmouth Junction, NJ, USA), IUPAC name: 6-amino-1,4-dihydro-4-[5-(hydroxymethyl)[1,1'-biphenyl]-3-yl]-3-methyl-4-(1-methylethyl)pyrano[2,3-c]pyrazole-5-carbonitrile) [22]

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a This table is an update of that of Cooper and Pinto, 2006, Cooper and Pinto, 2008 and Cooper et al

Con l'et, la produzione di collagene diminuisce, il che influisce direttamente sulla salute dei capelli riducendo l'elasticit del cuoio capelluto e la forza di ancoraggio dei follicoli