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In June 2022, the Medicines and Healthcare Products Regulatory Agency (MHRA) considered vitamin B12 deficiency a common side effect of metformin treatment

Some commons symptoms include: Fatigue Brain fog Decreased cognitive function such as issues with memory Lethargy Constipation Heart palpitations Vision changes Difficulty maintaining balance Headache Depression or irritability Feeling faint Sore or swollen tongue, or mouth ulcers Paresthesia (pins and needles) B-12 Injection Health Benefits Now you have a better understanding of the role that vitamin B-12 plays in the body you can understand that having a deficiency can lead to serious health problems

Important safety considerations include an increased risk of hypoglycaemia when used with insulin or sulfonylureas (dose reductions of these medications may be needed), potential risk of pancreatitis (seek urgent medical attention for severe, persistent abdominal pain), gallbladder disease, and risk of dehydration or acute kidney injury with severe gastrointestinal events

Below is a commonly referenced dosage guide based on clinical and experimental studies