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At one month after the last instillation, 90% of the patients reported relief of symptoms, but this rate declined to 46.7% and to 16.7% at 2 and 6-months, respectively

However, there have been new insights demonstrating that ONOO is also involved in various signaling pathways, including a mechanism of vasodilation independent of cGMP

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When differentiated into organoids, the AON-corrected line produced intestinal and kidney organoids that were indistinguishable from those derived from normal control iPSCs (data not shown), whereas the liver organoids exhibited partial recovery of ALB and CYP450 expression along with a marked attenuation of mesenchymal features (Supplementary Fig