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Theories include alteration of bile acid metabolism, small intestinal bacterial overgrowth, effects on intestinal motility and interference by metformin on vitamin B12-intrinsic factor absorption in the terminal ileum

If the injection goes too deep (into muscle) or too shallow (intradermal), absorption rates change, and the effective dose differs from the intended dose

There is also substantial research suggesting that BPC 157 helps to connect the GI tract to the brain by acting as a signaling molecule