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Indeed, the conversion of a catalytic Cys thiol into a disulfide is a powerful means for shutting down enzymatic activity because disulfides are poor nucleophiles compared to thiolates

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Beside modulation in HMGR expression, the authors also found a decreased expression of Peroxisome proliferator-activated receptor- coactivator-1 (PGC-1) at 1 week after tumor inoculation (Rosa-Caldwell et al., 2019)

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