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Gastrointestinal exposure to silica nanoparticles induced Alzheimers disease-like neurotoxicity in mice relying on gut microbiota and modulation through TLR4/NF-B and HDAC

[DOI] [PMC free article] [PubMed] [Google Scholar] Garway-Heath DF, Crabb DP, Bunce C, Lascaratos G, Amalfitano F, Anand N, Azuara-Blanco A, Bourne RR, Broadway DC, Cunliffe IA, Diamond JP, Fraser SG, Ho TA, Martin KR, McNaught AI, Negi A, Patel K, Russell RA, Shah A, Spry PG, Suzuki K, White ET, Wormald RP, Xing W, Zeyen TG, 2015

explored the potential effects and mechanism of baicalin and entecavir (ETV), which is a first-line anti-HBV drug, in HBV-DNA, HBsAg/HBeAg seroconversion and drug-resistance

By inhibiting this enzyme, 5-Amino-1MQ facilitates: Intracellular NAD+ Elevation: Supporting DNA repair, sirtuin (SIRT1) activity, and healthy cellular aging