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The pressure you apply to the skin through the gauze or cotton will also prevent the needle from pulling on the skin as it's removed, which can be painful

In one study from 1998 to 2000 in the USA and Canada, the reported rates were 0.3 cases of FISS per 10,000 vaccines and 11.8 post-vaccinal inflammatory reactions per 10,000 vaccinations in cats (Gobar and Kass, 2002)

Furthermore, these polysaccharides prompted intestinal IgA secretion through the activation of T cell-dependent and T cell-independent pathways, along with the stimulation and proliferation of B-cells, contributing to intestinal protection [38]