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But this research shows that, at normal biological levels, small increases in prostaglandin E2 can promote regeneration. A closer investigation of the chondrocytes in the joints of old mice and young mice showed that old chondrocytes expressed more detrimental genes involved in inflammation and the conversion of hyaline cartilage to unwanted bone, and fewer genes involved in cartilage development

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A gene's expression profile was considered associated with Lm if model 2 fit better than model 1 as determined by a significant P -value from a likelihood ratio test between the two models after applying a false discovery rate (FDR) correction